Development trend and prospect design of fermenter

2017-07-24 focus number:

With the improvement of fermentation tank biochemical technology and the increasing demand for biochemical products, higher and higher requirements have been put forward for the large-scale, energy-saving and efficient fermentation tank. At present, the volume of antibiotic fermenters in the world is mainly 80 ~ 200m, while 150 ~ 400m is commonly used in fermenters producing amino acids and citric acid. The volume of lysine of ADM company in the United States is 105U. S. Gal, equivalent to the nominal volume of 380m3. China's self-designed citric acid fermentation tank has reached 450m3. Fermentation is in sterile air bubbled into (or anaerobic) under the condition of complex biochemical process, also known as process under the condition of ventilation purebred submerged culture, thus design, not only is the design of the equipment, but also involved in the preparation of culture medium sterilization, sterile air, fermentation process control and process piping configuration of system engineering.


Technological process is an important index basis to measure whether an enterprise has advanced nature, whether it has market competitiveness and whether it can constantly lead competitors. With the rapid development of China's fermentation tank market, the core production technology application and research and development will become the focus of the industry. Understanding the development trend, process equipment, technology application and trend of core production technology at home and abroad is very important for enterprises to improve product technical specifications and market competitiveness.

After the 1990s, domestic equipment has been significantly improved, specifically in the following aspects.

The volume of antibiotic fermentation was expanded to 100 ~ 150m3. Lysine fermentation has reached 200m3; The citric acid fermentation has reached 450m3.


The production material is gradually changed from carbon steel to stainless steel.

Heat transfer was changed from a single tank with multiple vertical snake tubes to a semicircular outer coil with tank wall, supplemented by an inner cooling tube.


The driving gear reducer of the mixing tank is changed from belt reducer to gear reducer.


The agitator is changed from a single radial impeller to a combined axial and radial impeller.

However, as the system design of fermentation tanks has not been generally paid attention to, many production personnel of biological fermentation products often pay attention to the fermentation process and strains, or due to the capital and the current situation of fermentation plants, they do not pay enough attention to the large-scale and optimization of fermentation tanks. In terms of fermentation tank, the current domestic many factories was improved, based on the original 50 m3 tank diameter is 3100 mm, tank cylinder changes slightly, 60 m3 tank volume for 57 m3, such as motor power is 75 kw, 95 kw and 115 kw, the heat transfer of vertical coil, stirring impeller for six leaf worm gear, slowing down the pulley, thus it is necessary to improve its understanding of fermentation tank system design, the fermentation equipment along the direction of high efficiency, large and energy saving in our country further.


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